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No published human research has examined cosmetic outcomes in non-supervised settings, female subjects, or repeated long-term administration

While these mechanistic insights support the biological plausibility of IFs benefits, most data come from animal studies or short-term human trials, raising questions about their generalizability to long-term clinical outcomes

In other studies, Qb 1020 ml/min in neonates and infants has achieved clearance rates (total replacement and/or Qd) of 2,500 ml/1.73 m 2 /h 41,43

Moreover, very few studies rigorously assess patient-centred outcomes such as fatigue, mood, or quality of lifesymptoms that remain central concerns in euthyroid HT